Specimen: Polycystic Kidneys from a Case of Renal Rickets

Studies in a case of renal rickets.

The syndrome of secondary hyperparathyroidism due to chronic renal insufficiency is well recognized. A full discussion of the mechanisms involved can be found in Albright and Reifenstein's book (1948). Briefly, the sequence of events is renal insufficiency, phosphorus retention, a low serum calcium level and resulting parathyroid hyperplasia with skeletal changes and fiequently metastatic calif...

Prenatal diagnosis of infantile polycystic kidneys: a case report.

MEDICAL MEMORANDA Bilateral Renal Carcinoma associated with Polycystic Kidneys

Creutzfeldt disease and of hepatic coma is probably also due to a compensating action in the presence of a disordered dopaminergic system. Taken together, these findings suggest that triphasic waves occurring repetitively and regularly in an E.E.G. are caused by a disturbance of the dopaminergic system. The question arises whether the hyperkinesia and the coma are caused by disorders of two sep...

Erythropoietin in polycystic kidneys.

Erythropoietin (EPO) formation in kidneys of 18 patients with autosomal dominant polycystic kidney disease (ADPKD) was investigated. In 12 patients on hemodialysis and in 6 patients with preterminal renal failure serum, EPO was 29 +/- 7 and 16 +/- 1.5 mU/ml and hemoglobin concentrations were 11.0 +/- 0.6 and 12.7 +/- 1.2 g/dl, respectively. Cyst fluid from a total of 357 renal cysts was obtaine...

Gene profiling of polycystic kidneys.

BACKGROUND While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increa...